Jason A. Jarzembowski, MD, PhD

Associate Professor and Chief of Pediatric Pathology; Medical Director – Pathology and Laboratory Medicine; Program Director, Perinatal Pathology


pediatric pathology

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Jason A. Jarzembowski, MD, PhD

Assistant Professor


Phone: (414) 266-2526

FAX:      (414) 266-2779

Office Address

Children’s Hospital

9000 W Wisconsin Ave.

Milwaukee, WI 53226

Dr. Jarzembowski serves as Chief of Pediatric Pathology and Associate Professor of Pathology at the Medical College of Wisconsin and Medical Director of Pathology and Laboratory Medicine at Children’s Hospital of Wisconsin.

His clinical responsibilities include pediatric surgical pathology, placental/perinatal pathology, and autopsy pathology. He supervises a research program studying molecular abnormalities of the pediatric tumor neuroblastoma and is Vice-Chair of the Pathology Steering Committee for the Children’s Oncology Group. He leads the safe sleep initiative at Children’s Hospital and conducts research into sleep-related infant deaths. Dr. Jarzembowski is a member of the Editorial Board of the journals Pediatric and Developmental Pathology and the Archives of Pathology and Laboratory Medicine and is a fellow of both the College of American Pathologists and the American Society for Clinical Pathology. He is a Councilor-at-Large for the Society for Pediatric Pathology and is also an active member of the United States and Canadian Academy of Pathology, and Sigma Xi.

  • Research Interests
  • Professional Background
  • Educational Background
  • Board Certifications

Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL.

The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases.

J Biol Chem 2016 May 13;291(20):10948


Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL.

The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases.

J Biol Chem 2016 Mar 18;291(12):6534-45


Lyros O, Nie L, Moore T, Medda R, Otterson M, Behmaram B, Mackinnon A, Gockel I, Shaker R, Rafiee P.

Dysregulation of WNT5A/ROR2 Signaling Characterizes the Progression of Barrett-Associated Esophageal Adenocarcinoma.

Mol Cancer Res 2016 Jul;14(7):647-59


Lyros O, Rafiee P, Nie L, Medda R, Jovanovic N, Otterson MF, Behmaram B, Gockel I, Mackinnon A, Shaker R.

Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett's Esophagus: Regulation via Dickkopf-1.

Neoplasia 2015 Jul;17(7):598-611


Raychaudhuri R, Riese MJ, Bylow K, Burfeind J, Mackinnon AC, Tolat PP, Iczkowski KA, Kilari D.

Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm.

Clin Genitourin Cancer 2017 May 25;


Villarreal-Calderon R, Luévano-González A, Aragón-Flores M, Zhu H, Yuan Y, Xiang Q, Yan B, Stoll KA, Cross JV, Iczkowski KA, Mackinnon AC Jr.

Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori-positive and Helicobacter pylori-negative gastritis.

Ann Diagn Pathol 2014 Jun;18(3):129-35