NPM1 Mutation Analysis 
Mnemonic MISC
CPT 81310
Test Code 3509949
Synonyms CN-AML prognostication, NPM1 exon 12
Test Includes  
Specimen Whole Blood or Bone Marrow or Tissue
Volume 5.0 mL (3 mL Bone Marrow)
Container Lavender Top (EDTA) Tube
Special Instructions  
Specimen Prep Do NOT centrifuge
Storage Refrigerated
Transport Temp Refrigerated
Stability Rm Temp 24 hours
Stability Refrig 5 days
Stability Frozen Unacceptable
Methodology Polymerase Chain Reaction/Fragment Analysis
Rejection Criteria Whole blood OR Bone marrow: Frozen specimens. Clotted or grossly hemolyzed specimens. FFPE tumor tissue: Specimens fixed/processed in alternative fixatives or heavy metal fixatives (B-4 or B-5) or tissue sections on slides. Decalcified specimens. 
Reference Value   
Performed/TAT Three times per week   5-7 days    
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