Imipramine 
Mnemonic IMIPRAM
CPT 80335
Test Code 3507517
Synonyms Tofranil®, Imavate®, Presamine®
Test Includes Desipramine
Specimen Serum
Volume 1.0 mL
Container Red Top Tube. Do NOT use SSTs.
Special Instructions For therapeutic monitoring, collect specimen immediately prior to next dose.
Specimen Prep Centrifuge* For Red Top only, transfer serum to a Plastic Transport Tube.
Storage Refrigerate
Transport Temp Room Temperature
Stability Rm Temp 14 days
Stability Refrig 14 days
Stability Frozen 14 days
Methodology High Performance Liquid Chromatography /Tandem Mass Spectrometry (HPLC/MS/MS)
Rejection Criteria   
Reference Value 175 - 300 ng/mL; Critical Value: >500 ng/mL 
Performed/TAT Two times per week   Reported in 5-7 days    
Comments Imipramine reaches a peak serum concentration in 1-2 hours (desipramine 2-6 hours), has a half-life of 9-24 hours (desipramine 12-54 hours), and reaches steady-state levels in 2-5 days (desipramine 3-11 days).